Fruit flies and intellectual disability
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چکیده
منابع مشابه
Fruit flies and intellectual disability
Mental retardation—known more commonly nowadays as intellectual disability—is a severe neurological condition affecting up to 3% of the general population. As a result of the analysis of familial cases and recent advances in clinical genetic testing, great strides have been made in our understanding of the genetic etiologies of mental retardation. Nonetheless, no treatment is currently clinical...
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Aneuploidy is the presence of an abnormal number of chromosomes in cells. The gain or loss of a chromosome in germ cells is the most common cause of chromosomal aneuploidy. Trisomy 21, trisomy 18, and trisomy 13 are characterized by congenital anomalies with intellectual disability (ID) or short lives. Recently, mosaic variegated aneuploidy (the presence of a different number of chromosomes in ...
متن کاملInv21p12q22del21q22 and intellectual disability.
Chromosomal rearrangements are common in humans. Pericentric inversions are among the most frequent aberrations (1-2%). Most inversions are balanced and do not cause problems in carriers unless one of the breakpoints disrupts important functional genes, has near submicroscopic copy number variants or hosts "cryptic" complex chromosomal rearrangements. Pericentric inversions can lead to imbalanc...
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A method that can analyse the movements of Drosophila as they walk is a valuable addition to the tools available to neurobiologists, and has already led to insights into the interplay of central networks and sensory feedback in this model organism.
متن کاملFrom Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment
Intellectual disability (ID), previously known as mental retardation, affects 3% of the population and remains without pharmacological treatment. ID is characterized by impaired general mental abilities associated with defects in adaptive function in which onset occurs before 18 years of age. Genetic factors are increasing and being recognized as the causes of severe ID due to increased use of ...
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ژورنال
عنوان ژورنال: Fly
سال: 2009
ISSN: 1933-6934,1933-6942
DOI: 10.4161/fly.3.1.7812